Endocrine Abstracts

Regulatory circuits involving miRNAs and transcription factors (TFs) are prevalent mechanisms of gene expression by which developmental and pathologic processes occur. MiR-146b is one of the most upregulated and abundant oncomiRNAs in papillary thyroid carcinomas (PTCs). We have previously shown that miR-146b and PAX8 regulate each other and share common target genes such as NIS, thus highlighting a miR-146b-3p/PAX8/NIS regulatory circuit that governs the differentiated phenot...